Comparative effectiveness research for healthcare interventions in areas of high public health need

Deadline: 19 September 2023 & 11 April 2024

Expected Outcome:

This topic aims at supporting activities that are enabling or contributing to one or several expected impacts of destination 3 “Tackling diseases and reducing disease burden”.

  • Health policymakers are aware of the healthcare interventions (pharmacological, non-pharmacological or technological interventions;
  • Health professionals have access to and use the improved clinical guidelines on the optimal treatment of patients and prevention of diseases e.g. through vaccines. Considerations made in the guidelines include the harmonisation and standardisation of care for high burden diseases or conditions throughout Europe, as well as possible individualised needs of patients.
  • The scientific and clinical communities make effective use of state-of-the-art information, data, technologies, tools and best practices to develop interventions that are sustainable.
  • Citizens, patients, prescribers, and payers receive more accurate information on available healthcare interventions via ad hoc communication platforms.


Effective, affordable and accessible healthcare for diverse population groups is challenging and complex. The pediatric population, including children born preterm, has also its specific needs in specially adjusted therapeutics and early interventions to address emerging health and developmental problems. Similar to the elderly population, the pediatric population is often excluded from many clinical trials that generate the evidence base for healthcare interventions. Women, including pregnant women, are also often under-represented in clinical studies and access to quality healthcare is frequently inadequate. Other population groups with limited access to quality healthcare and/or under-representation in clinical studies include low-income groups, and refugees. Intersectionality within these groups also needs consideration.